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KMID : 0363420090230030177
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Journal of Korean Oriental Pediatrics
2009 Volume.23 No. 3 p.177 ~ p.191
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The Effect of InsamGobonHwan (IGH) on Growth of Rats
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Park Sun-Young
Baek Jung-Han
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Abstract
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Objectives: To evaluate the effect of InsamGobonHwan (IGH) on growth of rats.
Methods: We divided male Sprague-Dawley rats into 4 groups(IGHE1, IGHE2, IGHE3 and sham group). IGHE1, IGHE2, IGHE3 groups were administered with IGHE water extracts once a day at the dose of 1,000, 500 and 250㎎/㎏/10㎖ for 1 week, 2 weeks, and 3 weeks. Sham group was administered with normal saline with using the same method. We measured body weight, amount of body weight increasing, length of femur, serum Growth Hormone(GH), serum Insulin-like Growth Factor-Ⅰ(IGF-Ⅰ), serum Thyroid-stimulating Hormone(TSH) and serum testosterone at 1 week, 2 weeks, and 3 weeks of experiment.
Results: The body weight and the changes of body weight increased significantly in IGHE1 group compared to sham group after 2 and 3 weeks, and in IGHE2 group after 2 weeks. The lengths of the femur increased significantly in IGHE1 group as compared with sham group after 1, 2 and 3 weeks, and in IGHE3 group after 1 week. The level of IGF-Ⅰ in the serum increased significantly in S1 group as compared tosham group after 1 and 3 weeks, and in IGHE13 group after 3 weeks. The level of TSH in the serum increased significantly in IGHE1group as compared to sham group after 2 and 3 weeks. The level of GH and testosterone in the serum does not change significantly.
Conclusions: SGT have an effect of promoting growth of rats and might be effect to treat various kinds of growth
delay in children.
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KEYWORD
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InsamGobonHwan (IGH), growth, body weight, length of the femur, IGF-I, TSH
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